It's inspirational to learn about people who go on to great success after overcoming something that might otherwise make an individual abandon a goal. For example, Agatha Christie (one of my all-time favorite writers) suffered from dysgraphia.
Dysgraphia is a neurobiological learning disability that impairs an individual's ability to remember and learn the sequence of motor muscle movements necessary to write numbers and letters. This meant that Ms. Christie was unable to write legibly and had to dictate all of her books. So, even though she is credited with writing 93 books and 17 plays over her lifetime, she didn't actually "write" them. (Uhm, does that actually make her a dictator?)
Anyway, her success is proof that a "set-back" doesn't really have to be a wall. It's more of an rock in the path.